Seth Bordenstein

Seth Bordenstein

  • Dorothy Foehr Huck and J. Lloyd Huck Endowed Chair in Microbiome Sciences
  • Director of the Microbiome Center
  • Professor of Biology and Entomology
Huck Institutes of the Life Sciences
Pennsylvania State University
W-251 Millennium Science Complex
Pollock Road

University Park, PA 16802

Areas of Expertise

  • Endosymbiosis, Microbiome, Evolution, Phage Biology

Education

  • Postdoc, Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Lab, Woods Hole MA
  • Ph.D., Evolutionary Symbiosis, University of Rochester, Rochester NY
  • M.S., Evolutionary Genetics, University of Rochester, Rochester NY
  • B.S., Ecology and Evolutionary Biology, Biological Sciences | University of Rochester, Rochester NY

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*We are recruiting at all levels spanning lab manager, postdocs, and research professors; Please contact Dr. Bordenstein at s.bordenstein@psu.edu with a single pdf including cover letter, CV, and 1st authored papers, reports, and presentations. For more information on these projects and the lab, please visit https://bordensteinlab.com | See the jobXriv ad for more info*

Dr. Bordenstein has studied animal-microbe symbioses and microbiomes for 25 years. He is an evolutionary geneticist and microbiologist in the Departments of Entomology and Biology at Pennsylvania State University (PSU), University Park, PA. He is the the director of the PSU Microbiome Center and formerly the founding director of the Vanderbilt Microbiome Innovation Center and the worldwide HHMI-initiated science education program Discover the Microbes Within! The Wolbachia Project. He is also the Dorothy Foehr Huck and J. Lloyd Huck Endowed Chair in Microbiome Sciences

The Bordenstein laboratory endeavors to understand the evolutionary and genetic principles that shape symbiotic interactions between animals, microbes, and viruses and the major applications of these interactions to human health. Towards these goals, the lab employs hypothesis-driven approaches to molecularly unravel intimate symbioses between arthropods and obligate intracellular bacteria that modify sexual reproduction and facultative symbioses between animals and gut microbes that impact animal health, fitness, and evolution. The lab is helping to solve the next generation of endosymbiosis and microbiome challenges by (i) discovering the selfish bacteriophage WO genes, cytoplasmic incompatibility factor (cifA and cifB) and WO mediated killing (wmk), that alter arthropod sexual reproduction, (ii) establishing and coining the framework for phylosymbiosis, which is a cross-system host-microbiome pattern, (iii) revealing the first antibacterial gene from Archaea, and (iv) studying the persistent association of self-identified ethnicity and race with human microbiome variation in the United States.

Dr. Bordenstein is the recipient of the 2014 Jeffrey Nordhaus Award for Excellence in Undergraduate Teaching, 2014 Chancellor’s Award for Research, 2018 Chancellor Faculty Fellow Award from Vanderbilt University, and 2020 Genetics Society of America Award for Excellence in Education.

Publications

Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age
PLoS Biology, Mallott, Elizabeth K., Sitarik, Alexandra R., Leve, Leslie D., Cioffi, Camille, Camargo, Carlos A., Hasegawa, Kohei, Bordenstein, Seth R., 2023

Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease
Cells, Chioma, Ozioma S., Mallott, Elizabeth, Shah-Gandhi, Binal, Wiggins, Za Darreyal, Langford, Madison, Lancaster, Andrew William, Gelbard, Alexander, Wu, Hongmei, Johnson, Joyce E., Lancaster, Lisa, Wilfong, Erin M., Crofford, Leslie J., Montgomery, Courtney G., Van Kaer, Luc, Bordenstein, Seth, Newcomb, Dawn C., Drake, Wonder Puryear, 2023

Gut microbiota modulates lung fibrosis severity following acute lung injury in mice
Communications Biology, Chioma, Ozioma S., Mallott, Elizabeth K., Chapman, Austin, Van Amburg, Joseph C., Wu, Hongmei, Shah-Gandhi, Binal, Dey, Nandita, Kirkland, Marina E., Blanca Piazuelo, M., Johnson, Joyce, Bernard, Gordon R., Bodduluri, Sobha R., Davison, Steven, Haribabu, Bodduluri, Bordenstein, Seth R., Drake, Wonder P., 2022

Transgenic cytoplasmic incompatibility persists across age and temperature variation in Drosophila melanogaster
iScience, Ritchie, Isabella T., Needles, Kelly T., Leigh, Brittany A., Kaur, Rupinder, Bordenstein, Seth R., 2022

Individuality and ethnicity eclipse a short-term dietary intervention in shaping microbiomes and viromes
PLoS Biology, Li, Junhui, Markowitz, Robert H.George, Brooks, Andrew W., Mallott, Elizabeth K., Leigh, Brittany A., Olszewski, Timothy, Zare, Hamid, Bagheri, Minoo, Smith, Holly M., Friese, Katie A., Habibi, Ismail, Lawrence, William M., Rost, Charlie L., Lédeczi, Ákos, Eeds, Angela M., Ferguson, Jane F., Silver, Heidi J., Bordenstein, Seth R., 2022

Microbiome-associated human genetic variants impact phenome-wide disease risk
Proceedings of the National Academy of Sciences of the United States of America, Markowitz, Robert H.George, LaBella, Abigail Leavitt, Shi, Mingjian, Rokas, Antonis, Capra, John A., Ferguson, Jane F., Mosley, Jonathan D., Bordenstein, Seth R., 2022

A Margulian View of Symbiosis and Speciation: the Nasonia Wasp System
Symbiosis, Bell, Kara, Bordenstein, Seth R., 2022

The Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility
PLoS Biology, Kaur, Rupinder, Leigh, Brittany A., Ritchie, Isabella T., Bordenstein, Seth R., 2022

Comparison of qPCR and dPCR methods for the quantification of Wolbachia densities and arthropod gene expression.
Qiagen Application Note, Cross, K.L., Bordenstein, Seth, 2022

A single synonymous nucleotide change impacts the male-killing phenotype of prophage wo gene wmk
eLife, Perlmutter, Jessamyn I., Meyers, Jane E., Bordenstein, Seth R., 2021

The microbiome impacts host hybridization and speciation
PLoS Biology, Miller, Asia K., Westlake, Camille S., Cross, Karissa L., Leigh, Brittany A., Bordenstein, Seth R., 2021

New-onset vegetarian diet shows differences in fatty acid metabolites in European American and African American women
Nutrition, Metabolism and Cardiovascular Diseases, Wang, Naomi C., Bagheri, Minoo, Olszewski, Timothy, Friese, Katie A., Smith, Holly M., Robles, Michelle E., Wang, Chuan, Brooks, Andrew, Bordenstein, Seth R., Ferguson, Jane F., Silver, Heidi J., 2021

Microbiome reduction and endosymbiont gain from a switch in sea urchin life history
Proceedings of the National Academy of Sciences of the United States of America, Carrier, Tyler J., Leigh, Brittany A., Deaker, Dione J., Devens, Hannah R., Wray, Gregory A., Bordenstein, Seth R., Byrne, Maria, Reitzel, Adam M., 2021

Genomes of gut bacteria from nasonia wasps shed light on phylosymbiosis and microbe-assisted hybrid breakdown
mSystems, Cross, Karissa L., Leigh, Brittany A., Hatmaker, E. Anne, Mikaelyan, Aram, Miller, Asia K., Bordenstein, Seth R., 2021

Living in the endosymbiotic world of Wolbachia: A centennial review
Cell Host and Microbe, Kaur, R, Shropshire, J, Cross, Karissa, Leigh, Brittany, Mansueto, Alexander, Stewart, Victoria, Bordenstein, Sarah, Bordenstein, Seth R., 2021

The impacts of cytoplasmic incompatibility factor (cifA and cifB) genetic variation on phenotypes
Genetics, Shropshire, J. Dylan, Rosenberg, Rachel, Bordenstein, Seth R., 2021

The impact of artificial selection for wolbachia-mediated dengue virus blocking on phage wo
PLoS Neglected Tropical Diseases, Dutra, Heverton, Ford, Suzanne, Allen, Scott, Bordenstein, Sarah, Chenoweth, Stephen, Bordenstein, Seth, McGraw, Elizabeth A., 2021

Symbiont-mediated cytoplasmic incompatibility: What have we learned in 50 years?
eLife, Shropshire, J. Dylan, Leigh, Brittany, Bordenstein, Seth R., 2020

Visualizing the invisible: class excursions to ignite children’s enthusiasm for microbes
Microbial Biotechnology, McGenity, Terry J., Gessesse, Amare, Hallsworth, John E., Garcia Cela, Esther, Verheecke-Vaessen, Carol, Wang, Fengping, Chavarría, Max, Haggblom, Max M., Molin, Søren, Danchin, Antoine, Smid, Eddy J., Lood, Cédric, Cockell, Charles S., Whitby, Corinne, Liu, Shuang Jiang, Keller, Nancy P., Stein, Lisa Y., Bordenstein, Seth R., Lal, Rup, Nunes, Olga C., Gram, Lone, Singh, Brajesh K., Webster, Nicole S., Morris, Cindy, Sivinski, Sharon, Bindschedler, Saskia, Junier, Pilar, Antunes, André, Baxter, Bonnie K., Scavone, Paola, Timmis, Kenneth, 2020

An introduction to phylosymbiosis
Proceedings of the Royal Society B: Biological Sciences, Lim, Shen Jean, Bordenstein, Seth R., 2020

Microorganisms in the reproductive tissues of arthropods
Nature Reviews Microbiology, Perlmutter, Jessamyn I., Bordenstein, Seth R., 2020

Reply to Kenyon, “Are differences in the oral microbiome due to ancestry or socioeconomics?”
mSystems, Yang, Yaohua, Zheng, Wei, Cai, Qiuyin, Shrubsole, Martha J., Pei, Zhiheng, Brucker, Robert, Steinwandel, Mark, Bordenstein, Seth R., Li, Zhigang, Blot, William J., Shu, Xiao Ou, Long, Jirong, 2020

The emergence of microbiome centres
Nature Microbiology, Martiny, Jennifer, Whiteson, Katrine, Bohannan, Brendan, David, Lawrence, Hynson, Nicole, McFall-Ngai, Margaret, Rawls, John, Schmidt, Thomas, Abdo, Zaid, Blaser, Martin, Bordenstein, Seth, Bréchot, Christian, Bull, Carolee T., Dorrestein, Pieter, Eisen, Jonathan, Garcia-Pichel, Ferran, Gilbert, Jack, Hofmockel, Kirsten, Holtz, Mary, Knight, Rob, Mark Welch, David, McDonald, Daniel, Methé, Barbara, Mouncey, Nigel, Mueller, Noel, Pfister, Catherine, Proctor, Lita, Sachs, Joel, 2020

Author Correction: The Wolbachia mobilome in Culex pipiens includes a putative plasmid (Nature Communications, (2019), 10, 1, (1051), 10.1038/s41467-019-08973-w)
Nature Communications, Reveillaud, Julie, Bordenstein, Sarah R., Cruaud, Corinne, Shaiber, Alon, Esen, Özcan C., Weill, Mylène, Makoundou, Patrick, Lolans, Karen, Watson, Andrea R., Rakotoarivony, Ignace, Bordenstein, Seth R., Eren, A. Murat, 2019

Cigarette smoking and oral microbiota in low-income and African-American populations
Journal of Epidemiology and Community Health, Yang, Yaohua, Zheng, Wei, Cai, Qiu Yin, Shrubsole, Martha J., Pei, Zhiheng, Brucker, Robert, Steinwandel, Mark D., Bordenstein, Seth R., Li, Zhigang, Blot, William J., Shu, Xiao Ou, Long, Jirong, 2019

Paternal grandmother age affects the strength of Wolbachia-induced cytoplasmic incompatibility in Drosophila melanogaster
mBio, Layton, Emily M., On, Jungmin, Perlmutter, Jessamyn I., Bordenstein, Seth R., Shropshire, J. Dylan, 2019

Microbiota and the social brain
Science, Sherwin, Eoin, Bordenstein, Seth R., Quinn, John L., Dinan, Timothy G., Cryan, John F., 2019

Phylosymbiosis impacts adaptive traits in nasonia wasps
mBio, van Opstal, Edward J., Bordenstein, Seth R., 2019

Corrigendum: Evolutionary genetics of cytoplasmic incompatibility genes cifA and cifB in prophage WO of Wolbachia (Genome Biology and Evolution (2018) 10 (434-451) DOI: 10.1093/gbe/evy012)
Genome Biology and Evolution, Lindsey, Amelia R.I., Rice, Danny W., Bordenstein, Sarah R., Brooks, Andrew W., Bordenstein, Seth R., Newton, Irene L.G., 2019

The phage gene wmk is a candidate for male killing by a bacterial endosymbiont
PLoS Pathogens, Perlmutter, Jessamyn, Bordenstein, Sarah, Unckless, Robert, LePage, Daniel, Metcalf, Jason, Hill, Tom, Martinez, Julien, Jiggins, Francis, Bordenstein, Seth R., 2019

Minimum information about an uncultivated virus genome (MIUVIG)
Nature Biotechnology, Roux, Simon, Adriaenssens, Evelien M., Dutilh, Bas E., Koonin, Eugene V., Kropinski, Andrew M., Krupovic, Mart, Kuhn, Jens H., Lavigne, Rob, Brister, J. Rodney, Varsani, Arvind, Amid, Clara, Aziz, Ramy K., Bordenstein, Seth R., Bork, Peer, Breitbart, Mya, Cochrane, Guy R., Daly, Rebecca A., Desnues, Christelle, Duhaime, Melissa B., Emerson, Joanne B., Enault, François, Fuhrman, Jed A., Hingamp, Pascal, Hugenholtz, Philip, Hurwitz, Bonnie L., Ivanova, Natalia N., Labonté, Jessica M., Lee, Kyung Bum, Malmstrom, Rex R., Martinez-Garcia, Manuel, Mizrachi, Ilene Karsch, Ogata, Hiroyuki, Páez-Espino, David, Petit, Marie Agnès, Putonti, Catherine, Rattei, Thomas, Reyes, Alejandro, Rodriguez-Valera, Francisco, Rosario, Karyna, Schriml, Lynn, Schulz, Frederik, Steward, Grieg F., Sullivan, Matthew B., Sunagawa, Shinichi, Suttle, Curtis A., Temperton, Ben, Tringe, Susannah G., Thurber, Rebecca Vega, Webster, Nicole S., Whiteson, Katrine L., Wilhelm, Steven W., Wommack, K. Eric, Woyke, Tanja, Wrighton, Kelly C., Yilmaz, Pelin, Yoshida, Takashi, Young, Mark J., Yutin, Natalya, Allen, Lisa Zeigler, Kyrpides, Nikos C., Eloe-Fadrosh, Emiley A., 2019

Racial differences in the oral microbiome: Data from low-income populations of African ancestry and European ancestry
mSystems, Yang, Yaohua, Zheng, Wei, Cai, Qiuyin, Shrubsole, Martha J., Pei, Zhiheng, Brucker, Robert, Steinwandel, Mark, Bordenstein, Seth R., Li, Zhigang, Blot, William J., Shu, Xiao Ou, Long, Jirong, 2019

Models and Nomenclature for Cytoplasmic Incompatibility: Caution over Premature Conclusions – A Response to Beckmann et al.
Trends in Genetics, Shropshire, J, Leigh, Brittany, Bordenstein, Sarah, Duplouy, Anne, Riegler, Markus, Brownlie, Jeremy, Bordenstein, Seth R., 2019

The Wolbachia mobilome in Culex pipiens includes a putative plasmid
Nature Communications, Reveillaud, Julie, Bordenstein, Sarah, Cruaud, Corinne, Shaiber, Alon, Esen, Özcan C., Esen, \"Ozcan C, None, Weill, Mylène, Weill, Myl\`ene, None, Makoundou, Patrick, Lolans, Karen, Watson, Andrea, Rakotoarivony, Ignace, Bordenstein, Seth R., others, None, Eren, A. Murat, 2019

Gut microbiota diversity across ethnicities in the United States
PLoS Biology, Brooks, Andrew W., Priya, Sambhawa, Blekhman, Ran, Bordenstein, Seth R., 2018

Microbe profile: Wolbachia: A sex selector, a viral protector and a target to treat filarial nematodes
Journal of General Microbiology, Taylor, Mark J., Bordenstein, Seth R., Slatko, Barton, 2018

Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure
PLoS One, Romano-Keeler, Joann, Shilts, Meghan H., Tovchigrechko, Andrey, Wang, Chunlin, Brucker, Robert M., Moore, Daniel J., Fonnesbeck, Christopher, Meng, Shufang, Correa, Hernan, Lovvorn, Harold N., Tang, Yi Wei, Hooper, Lora, Bordenstein, Seth R., Das, Suman R., Weitkamp, Jorn Hendrik, 2018

Microbial Misandry: Discovery of a Spiroplasma Male-Killing Toxin
Cell Host and Microbe, Perlmutter, Jessamyn I., Bordenstein, Seth R., 2018

The Maternal Effect Gene Wds Controls Wolbachia Titer in Nasonia
Current Biology, Funkhouser-Jones, Lisa J., van Opstal, Edward J., Sharma, Ananya, Bordenstein, Seth R., 2018

One prophage WO gene rescues cytoplasmic incompatibility in Drosophila melanogaster
Proceedings of the National Academy of Sciences of the United States of America, Dylan Shropshire, J., On, Jungmin, Layton, Emily M., Zhou, Helen, Bordenstein, Seth R., 2018

Gut microbes limit growth in house sparrow nestlings (Passer domesticus) but not through limitations in digestive capacity
Integrative Zoology, Kohl, Kevin D., Brun, Antonio, Bordenstein, Seth R., Caviedes-Vidal, Enrique, Karasov, William H., 2018

Finer-scale phylosymbiosis: Insights from insect viromes
mSystems, Leigh, Brittany, Bordenstein, Sarah, Brooks, Andrew, Mikaelyan, Aram, Bordenstein, Seth R., 2018

Evolutionary Genetics of Cytoplasmic Incompatibility Genes cifA and cifB in Prophage WO of Wolbachia
Genome Biology and Evolution, Lindsey, Amelia, Rice, Danny, Bordenstein, Sarah, Brooks, Andrew, Bordenstein, Seth, Newton, Irene, 2018

Chromosomal localization of Wolbachia inserts in the genomes of two subspecies of Chorthippus parallelus forming a Pyrenean hybrid zone
Chromosome Research, Toribio-Fernández, Raquel, Bella, José L., Martínez-Rodríguez, Paloma, Funkhouser-Jones, Lisa J., Bordenstein, Seth R., Pita, Miguel, 2017

Parasite microbiome project: Systematic investigation of microbiome dynamics within and across parasite-host interactions
mSystems, Dheilly, Nolwenn M., Bolnick, Daniel, Bordenstein, Seth, Brindley, Paul J., Figuères, Cédric, Holmes, Edward C., Martínez, Joaquín Martínez, Phillips, Anna J., Poulin, Robert, Rosario, Karyna, 2017

Association of oral microbiome with type 2 diabetes risk
Journal of Periodontal Research, Long, J., Cai, Q., Steinwandel, M., Hargreaves, M. K., Bordenstein, S. R., Blot, W. J., Zheng, W., Shu, X. O., 2017

Gut microbial ecology of lizards: insights into diversity in the wild, effects of captivity, variation across gut regions and transmission
Molecular Ecology, Kohl, Kevin D., Brun, Antonio, Magallanes, Melisa, Brinkerhoff, Joshua, Laspiur, Alejandro, Acosta, Juan Carlos, Caviedes-Vidal, Enrique, Bordenstein, Seth R., 2017

Establishment of F1 hybrid mortality in real time
BMC Evolutionary Biology, Saulsberry, Ashley, Pinchas, Marisa, Noll, Aaron, Lynch, Jeremy A., Bordenstein, Seth R., Brucker, Robert M., 2017

Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility
Nature, LePage, Daniel, Le Page, Daniel P., Metcalf, Jason, Bordenstein, Sarah, On, Jungmin, Perlmutter, Jessamyn, Shropshire, J, Layton, Emily, Funkhouser-Jones, Lisa, Beckmann, John, Bordenstein, Seth R., 2017

Phylosymbiosis: Relationships and Functional Effects of Microbial Communities across Host Evolutionary History
PLoS Biology, Brooks, Andrew W., Kohl, Kevin D., Brucker, Robert M., van Opstal, Edward J., Bordenstein, Seth R., 2016

Disentangling a holobiont - recent advances and perspectives in Nasonia wasps
Frontiers in Microbiology, Dittmer, Jessica, van Opstal, Edward J., Shropshire, J. Dylan, Bordenstein, Seth R., Hurst, Gregory D.D., Brucker, Robert M., 2016

Fecal Transplants: What Is Being Transferred?
PLoS Biology, Bojanova, Diana P., Bordenstein, Seth R., 2016

Physiological and microbial adjustments to diet quality permit facultative herbivory in an omnivorous lizard
Journal of Experimental Biology, Kohl, Kevin D., Brun, Antonio, Magallanes, Melisa, Brinkerhoff, Joshua, Laspiur, Alejandro, Acosta, Juan Carlos, Bordenstein, Seth R., Caviedes-Vidal, Enrique, 2016

Wolbachia pipientis should not be split into multiple species: A response to Ramírez-Puebla et al.
Systematic and Applied Microbiology, Lindsey, Amelia R.I., Bordenstein, Seth R., Newton, Irene L.G., Rasgon, Jason L., 2016

Comparative genomics of two closely related wolbachia with different reproductive effects on hosts
Genome Biology and Evolution, Newton, Irene L.G., Clark, Michael E., Kent, Bethany N., Bordenstein, Seth R., Qu, Jiaxin, Richards, Stephen, Kelkar, Yogeshwar D., Werren, John H., 2016

Wolbachia mosquito control: Regulated
Science, Dobson, Stephen L., Bordenstein, Seth R., Rose, Robert I., 2016

Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency
Nature Communications, Richmond, Bradley W., Brucker, Robert M., Han, Wei, Du, Rui Hong, Zhang, Yongqin, Cheng, Dong Sheng, Gleaves, Linda, Abdolrasulnia, Rasul, Polosukhina, Dina, Clark, Peter E., Bordenstein, Seth R., Blackwell, Timothy S., Polosukhin, Vasiliy V., 2016

Speciation by symbiosis: The microbiome and behavior
mBio, Shropshire, J. Dylan, Bordenstein, Seth R., 2016

Getting the hologenome concept right: An eco-evolutionary framework for hosts and their microbiomes
mSystems, Theis, Kevin R., Dheilly, Nolwenn M., Klassen, Jonathan L., Brucker, Robert M., Baines, John F., Bosch, Thomas C.G., Cryan, John F., Gilbert, Scott F., Goodnight, Charles J., Lloyd, Elisabeth A., Sapp, Jan, Vandenkoornhuyse, Philippe, Zilber-Rosenberg, Ilana, Rosenberg, Eugene, Bordenstein, Seth R., 2016

Eukaryotic association module in phage WO genomes from Wolbachia
Nature Communications, Bordenstein, Sarah, Bordenstein, Seth R., 2016

An optimized approach to germ-free rearing in the jewel wasp Nasonia
PeerJ, Shropshire, J. Dylan, van Opstal, Edward J., Bordenstein, Seth R., 2016

I Contain Multitudes (Ed Yong, Harper Collins) Lean on we: How eco-evolution permeates animal-microbe associations
Trends in Ecology and Evolution, Bordenstein, Seth, 2016

Rethinking heritability of the microbiome
Science, Van Opstal, Edward J., Bordenstein, Seth R., 2015

Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery
Nature Communications, Flynn, Charles Robb, Albaugh, Vance L., Cai, Steven, Cheung-Flynn, Joyce, Williams, Phillip E., Brucker, Robert M., Bordenstein, Seth R., Guo, Yan, Wasserman, David H., Abumrad, Naji N., 2015

Wolbachia co-infection in a hybrid zone: Discovery of horizontal gene transfers fromtwoWolbachia supergroups into an animal genome
PeerJ, Funkhouser-Jones, Lisa J., Sehnert, Stephanie R., Martínez-Rodríguez, Paloma, Toribio-Fernández, Raquel, Pita, Miguel, Bella, José L., Bordenstein, Seth R., 2015

Tandem-repeat protein domains across the tree of life
PeerJ, Jernigan, Kristin K., Bordenstein, Seth R., 2015

Host biology in light of the microbiome: Ten principles of holobionts and hologenomes
PLoS Biology, Bordenstein, Seth R., Theis, Kevin R., 2015

Antibacterial gene transfer across the tree of life
eLife, Metcalf, Jason A., Funkhouser-Jones, Lisa J., Brileya, Kristen, Reysenbach, Anna Louise, Bordenstein, Seth R., 2014

Early life establishment of site-specific microbial communities in the gut
Gut Microbes, Rromano-Keeler, Joann, Moore, Daniel J., Wang, Chunlin, Brucker, Rrobert M., Fonnesbeck, Christopher, Slaughter, James C., Li, Haijing, Curran, Danielle P., Meng, Shufang, Correa, Hernan, Lovvorn, Harold N., Tang, Yyi Wei, Bordenstein, Seth, George, Aalfred L., Weitkamp, Jörn Hendrik, 2014

Ankyrin domains across the tree of life
PeerJ, Jernigan, Kristin K., Bordenstein, Seth R., 2014

Recent genome reduction of Wolbachia in Drosophila recens targets phage WO and narrows candidates for reproductive parasitism
PeerJ, Metcalf, Jason A., Jo, Minhee, Bordenstein, Sarah R., Jaenike, John, Bordenstein, Seth R., 2014

Friends with social benefits: Host-microbe interactions as a driver of brain evolution and development?
Frontiers in cellular and infection microbiology, Stilling, Roman M., Bordenstein, Seth R., Dinan, Timothy G., Cryan, John F., 2014