Beth McGraw, PhD

Beth McGraw, PhD

  • Professor and Huck Scholar in Entomology
W251 Millennium Science Complex
University Park, PA 16802

Education

  • Postdoc, University of Queensland 2001
  • Postdoc, Yale Medical School 1998-2001
  • Ph.D. Biology, Pennsylvania State University 1998
  • B.S. Biology, University of Michigan 1993

Connect with Elizabeth A McGraw, PhD
Twitter @McGrawLab

Website
Detailed information about research interests, publications and current lab members can be found at our website

Areas of research interest
Vector biology
Arboviruses
Host:pathogen evolution
Insect endosymbionts

Research
My research group studies the genetic basis of mosquito vector:pathogen:endosymbiont interactions.  Specifically, we are interested in how genetic diversity and coevolutionary forces in these three partners affect transmission of arboviruses.  We use quantitative genetic, experimental evolution, genomic and molecular biology approaches.  

Selected publications

Novelo, M, Hall, Pak, D, MD, Young, PR, Holmes, EC, McGraw EA. 2020. Intra-host growth kinetics of dengue virus in the mosquito Aedes aegypti. PLOS Pathog. 15:e1008218.

Ford SA, Allen SL, Ohm JR, Sigle LT, Sebastian A, Albert I, Chenoweth SF, McGraw EA. 2019. Selection on Aedes aegypti alters Wolbachia-mediated dengue virus blocking and fitness. Nat Microbiol. 4:1832-1839.

Audsley, MD, Selezenv, A, Joubert, DA, Woolfit, M, O’Neill, SL and McGraw EA. 2018. Wolbachia infection alters the relative abundance of resident bacteria an adult Aedes aegypti mosquitoes, but not larvae. Mol Ecol. 27:297-309.

Haqshenas, G, Terradas, G, Paradkar, PN, Duchemin, JB, McGraw, EA and Doerig, C. 2018. A role for the insulin receptor in the suppression of dengue virus and Zika virus in Wolbachia-infected mosquito cells. Cell Reports 26:529-535.e3

Terradas G, Joubert, DA, McGraw EA. 2017. Wolbachia-mediated blocking of dengue virus in mosquito cells is due in part to the action of the RNAi pathway. Sci Rep 7:43847.

Ye, YH, Chenoweth, SF, Carrasco, AM, Allen, SF, Frentiu, FD, van den Hurk, AF, Beebe, NW, McGraw, EA. 2016. Evolutionary potential of the extrinsic incubation period of dengue virus in Aedes aegypti. Evolution 70:2459-2469.

Lambrechts, L, Ferguson, NM, Harris, E, Holmes, EC, McGraw, EA, O'Neill, SL, Ooi, EE, Ritchie, SA, Ryan, PA, Scott, TW, Simmons, CP, Weaver, SC. 2015. Pragmatically assessing the efficacy of Wolbachia deployments for dengue biocontrol. Lancet Infect Dis 15:862-866.

Ferguson, NM, Kien, DTH, Clapham, H, Aguas, R, Trung, VT, Bich, TN, Popovici, J, Ryan, PA, O'Neill, SL, McGraw, EA, Long, VT, Dui, LT, Nguyen, HL, Chau, NV, Simmons, CP. 2015. Modeling the impact on virus transmission of Wolbachia-mediated blocking of dengue virus infection of Aedes aegypti. Sci Trans Med 7:279ra37.

Caragata, EP, Rances, E, Hedges, LM, Gofton, AW, Johnson, KN, O'Neill, SL, McGraw, EA, 2013. Dietary cholesterol modulates pathogen blocking by Wolbachia. PLOS Pathog 9: e1003459.

McGraw EA, O'Neill SL, 2013. Beyond insecticides: new thinking on an ancient problem. Nat Rev Microbiol 11:181-93

Hoffmann AA, Montgomery BL, Popovici J, Iturbe-Ormaetxe I, Johnson PH, Muzzi F, Greenfield M, Durkan M, Leong YS, Dong Y, Cook H, Axford J, Callahan AG, Kenny N, Omodei C, McGraw EA, Ryan PA, Ritchie SA, Turelli M, O'Neill SL, 2011. Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission. Nature 476: 454-457.

Moreira LA, Iturbe-Ormaetxe I, Jeffery JA, Lu G, Pyke AT, Hedges LM, Rocha BC, Hall-Mendelin S, Day A, Riegler M, Hugo LE, Johnson KN, Kay BH, McGraw EA, van den Hurk AF, Ryan PA, O'Neill SL, 2009. A Wolbachia symbiont in Aedes aegypti limits infection with dengue, chikungunya, and Plasmodium. Cell 139: 1268-1278.

Ye YH, Chenoweth SF, McGraw EA, 2009. Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogaster. PLOS Pathog 5:e1000385.