Rudolf Schilder, Ph.D.
- Postdoctoral fellow, 2008-2011. Penn State Hershey, Hershey, PA.
- Postdoctoral fellow, 2006-2008. University of Nebraska, Lincoln, NE.
- Ph.D. Biology, Penn State University, University Park, PA.
- M.Sc. Biology, Wageningen University and Research Center, The Netherlands.
The success or fitness of animals depends to a large extent on how well they respond to changes in demands from their environment. I am broadly interested in the (physiological) mechanisms that allow them to do this most optimally, but my research in this area is mainly focused on how animals match the performance of their locomotory apparatus (i.e. their musculoskeletal system) to changes in their body size, energy requirements and energy availability. As most organisms have to deal with these issues, I am not limited in the type of animal I can study. In fact, by studying these mechanisms across different animal taxa we may identify important evolutionary constraints on animal design (in a broad sense), and sources of design variation that natural selection may act on.
Zera, A J, C. Wehrkamp, R. Schilder, C. Black, and P. Gribben (2014). Purification and Characterization of 6-Phosphogluconate Dehydrogenase From the Wing-Polymorphic Cricket, Gryllus Firmus, and Assessment of Causes of Morph-Differences in Enzyme Activity. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. doi:10.1016/j.cbpb.2014.04.001.
N. N. Vellichirammal, A. J. Zera, R. J. Schilder, C. Wehrkamp, J-J. M. Riethoven, J. A. Brisson (2014). De novo transcriptome assembly and morph-specific gene expression profiling of the wing polymorphic cricket Gryllus firmus.PLoSONE DOI: 10.1371/journal.pone.0082129.
A. Kelleher, S. R. Kimball, M.D. Dennis, Alex P. Tuckow, R. J. Schilder, L. S. Jefferson (2013). The repressors of mTORC1 signaling, REDD1 and REDD2, are rapidly induced in skeletal muscle of an immobilized rat hindlimb. Am J Physiol Endocrinol Metab 304(2): E229-36.
J. H. Marden, H. W. Fescemeyer, R. J. Schilder, W. R. Doerfler, C. W. Wheat (2012). Genetic variation in HIF signalling underlies quantitative variation in life history traits within lowland populations. Evolution 67(4): 1105-1115; COVER Article.
R. J. Schilder, S. R. Kimball, L. S. Jefferson (2012). Cell-autonomous regulation of fast Troponin T pre-mRNA alternative splicing in response to mechanical stretch. American Journal of Physiology - Cell Physiology 303, C298-C307.
R. J. Schilder, A. J. Zera, C. Black, M. Hoidal, and P. Gribben (2011) . The biochemical basis of life history adaptation: Molecular and enzymological causes of NADP+-isocitrate dehydrogenase activity differences between morphs of Gryllus firmus that differ in lipid biosynthesis and life history. Molecular Biology and Evolution 28, 3381-3393.
R. J. Schilder, S. R. Kimball, J. H. Marden, and L. S. Jefferson (2011). Body weight-dependent troponin T alternative splicing is evolutionarily conserved from insects to mammals and partially impaired in skeletal muscle of obese rats, The Journal of Experimental Biology 214: 1523-1532.
R. J. Schilder, J. H. Marden (2007). Parasites, proteomics, and performance: effects of gregarine gut parasites on dragonfly flight muscle composition and function. The Journal of Experimental Biology 210, 4298-4306.
R. J. Schilder, J. H. Marden (2007). Metabolic syndrome in insects triggered by gut microbes. Journal of Diabetes Science and Technology 1, 794-796.
R. J. Schilder, J. H. Marden (2006). Metabolic syndrome and obesity in an insect. Proceedings of the National Academy of Science USA 103, 18805-18809.
R. J. Schilder, J. H. Marden (2004). A hierarchical analysis of the scaling of force and power output by dragonfly flight motors. The Journal of Experimental Biology 207, 767-776.