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Liwang Cui, Ph.D.

  • Professor
Liwang Cui, Ph.D.
537 Ag Sciences & Industries Building
University Park, PA 16802
Email:
Work Phone: 814-863-7663

Education

  1. B.S., Shenyang Agricultural University, 1984
  2. Ph.D., Moldova Agricultural University, 1991
  3. Ph.D., University of Kentucky, 1996

Liwang Cui - Lab Website
Google Scholar Profile

Current Graduate Students:
Awtum Brashear
Xiaoying Liang

Department Focus Areas:
Disease Ecology and Biology

Research Interests :

  • Molecular parasitology
  • Malaria
  • Host-parasite interactions

Teaching:
Insect Genomics, Proteomics and Bioinformatics
Biology of Animal Parasites 
Insect Pathology

 

Research Activities & Interests:

1. Malaria parasite developmental biology

Malaria is a parasitic disease caused by the protozoan parasites of the genus Plasmodium. The annual 300-500 million malaria cases and the resulting ~1 million deaths are a major public health problem and huge burden for economic development in many regions of the world. Malaria parasite transmission from the vertebrate host to the mosquito vector requires sexual development of the parasite in the vertebrate host, a process termed gametocytogenesis. While the transition from asexual multiplication to sexual differentiation is triggered by many external factors, the underlying molecular mechanisms are still poorly understood. Our study focuses on functional analysis of Puf RNA-binding protein family proteins, which showed different expression profiles during parasite life cycle. The Puf protein family are evolutionarily conserved translational repressors in eukaryotes. They bind to the cis-acting elements residing in the 3' untranslated region (3'UTR) of cytoplasmic mRNAs and block the translation of these mRNAs. We use in vitro biochemical and molecular approaches and in vivo genetic knockout to study the functions of Puf proteins during the development of the malaria parasite.

2. Malaria parasite epigenetics

Genomic DNA in eukaryotes is packed with histones into chromatin, which serves as the scaffold on which the basic cellular processes of DNA replication, repair, and transcription take place. The structure of chromatin is dynamic, affected by three major processes: 1) ATP-dependent chromatin remodeling complex such as SWI/SNF; 2) eviction and incorporation of variant histones such as H2A.Z and H3 variants; and 3) covalent, posttranslational modifications of histones. The histone tails are subject to various including phosphorylation, acetylation, methylation, ADP-ribosylation, ubiquitination, and sumoylation. Different modifications affect the histone‑DNA interactions and act sequentially or in combination to create an epigenetic code termed “the histone code”. Enzymes that regulate these processes have become potential targets for developing novel chemotherapy of diseases.

The malaria parasites also have a typical nucleosomal organization involving core and variant histones that are dynamically modified throughout development. The parasite genome encodes most of the histone modification enzymes. Recent studies suggest that they could serve as key regulators of gene expression and many cellular processes are probably controlled epigenetically. This includes the antigenic switch, mediated by the monoallelic expression of some 60 var genes. Our research in this area focuses on the enzymes conferring modifications on the lysine residues in the N-terminal tails of the core histones H3 and H4 using the P. falciparum system. Our study employs parasite transfection and gene knockout, chromatin immunoprecipitation, microarrays, proteomics and other gene expression analysis.

3. Malaria epidemiology and population biology

Accurate knowledge of malaria epidemiology is essential for deploying targeted control strategies to malaria control, especially during the elimination phase of malaria. We are interested in the changing picture of malaria epidemiology in Southeast Asia. In this region, all four human malaria parasites are present and their prevalences show dramatic spatial and temporal variations. Our study focuses on malaria epidemiology along international borders, especially at our study sites in Thailand, China and Myanmar. We want to determine the population structures of the parasites in response to control measures and under different endemic settings.  We are also interested in the evolution of genes involved in drug resistance and evasion of host immunity.

4. Mechanisms of drug resistance

One major impediment in malaria control is development of the parasites to multiple antimalarial drugs. The recently detected reduced sensitivity of P. falciparum parasites to artemisinin derivatives at the Thai-Cambodian border raised considerable concerns. We are interested in studying the molecular epidemiology of drug resistance in malaria parasites,  in vitro monitoring of drug resistance at setinel sites, and elucidating molecular mechanisms underlying drug resistance especially to artemisinin-related drugs. We use a panel of molecular and genetic tools (parasite transfection, genome-wide association studies - GWAS, microarray and proteomics) to study the development of drug resistance in field isolates and in laboratory selected resistant strains.

Relevant Publications

2016

Guo, S., Cui, Y., Wang, K., Zhang, W., Tan, G., Wang, B.,  Cui, L.  2016. Development of a specific monoclonal antibody for the quantification of artemisinin in Artemisia annua and rat serum. Anal. Chem. 88, 2701-2706.

Hu, Y., Zhou, G., Ruan, Y., Lee, M.-C., Xu, X., Deng, S., Bai, Y., Zhang, J., Morris, J., Liu, H., Wang, Y., Fan, Q., Li, P., Yang, Z.,  Yan, G.,  Cui, L.  2016. Seasonal dynamics and micro-geographical spatial heterogeneity of malaria along the China-Myanmar border. Acta Trop. 157, 12-19.

Zhu, X., Zhao, Z., Feng, Y., Li, P., Liu, F., Liu, J., Yang, Z., Yan, G., Fan, Q., Cao, Y., Cui, L. 2016. Genetic diversity of the Plasmodium falciparum apical membrane antigen I gene in parasite population from the China-Myanmar border area. Infect. Genet. Evol. 39, 155-162.

Liu, H., Feng, G., Zeng, W., Li, X., Bai, Y., Deng, S., Ruan, Y., Morris, J., Li, S., Yang, Z., Cui, L. 2016. A more appropriate white blood cell count for estimating malaria parasite density in Plasmodium vivax patients in northeastern Myanmar. Acta Trop. 156, 152-156.

Sriwichai, P., Samung, Y., Sumroypol, S., Kiattibutr, K., Kumpitak, C., Payakapon, A., Kaewkungwal, J., Yan, G., Cui, L., Sattabongkot, J. 2016. Natural human Plasmodium infections in major Anopheles mosquitoes in western Thailand. Parasit. Vectors 9, e17.

2015

Sriwichai, P., Karl, S., Samung, Y., Sumroypol, S., Kiattibutr, K., Payakapon, A., Mueller, I., Yan, G., Cui, L., Sattabongkot, J. 2015. Evaluation of CDC light traps for mosquito surveillance in a malaria endemic area on the Thai-Myanmar border. Parasit. Vectors 8, e636.

Xia, H., Jangpatarapongsa, K., Fang, Q., Tao Z., Miao, J., Cui, L., Li, B., Udomsangpetch, R. 2015. A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings. EXCLI J. 14, 926-934.

Feng, H., Gupta, B., Wang, M., Zheng, W., Zheng, L., Zhua, X., Yang, Y., Fang, Q., Luo, E., Fan, Q., Tsuboi, T., Cao, Y.,  Cui, L.  2015. Genetic diversity of transmission-blocking vaccine candidate Pvs48/45 in Plasmodium vivax populations in China. Parasit. Vectors 8, 615.

Reddy, B.P.N., Shrestha, S., Hart, K.J., Liang, X., Kemirembe, K., Cui, L., Lindner, S.E.  2015. A bioinformatic survey of RNA-binding proteins in Plasmodium. BMC Genomics 16, e890.

Cabrera, M., Cui, L. 2015. In vitro activities of primaquine-schizonticide combinations on asexual blood stages and gametocytes of Plasmodium falciparum. Antimicrob. Agents Chemother. 59, 7650-7656.

Wang, Z., Wang, Y., Cabrera, M., Zhang, Y., Gupta, B., Wu, Y., Kemirembe, K., Hu, Y., Liang, X., Brashear, A., Shrestha, S., Li, X., Miao, J., Sun, X., Yang, Z., Cui, L. 2015. Artemisinin resistance at the China-Myanmar border and association with mutations in the K13-propeller gene. Antimicrob. Agents Chemother. 59, 6952-6959.

Wang, Y., Zhong, D., Cui, L., Lee, M.-C., Yang, Z., Yan, G., Zhou, G. 2015. Population dynamics and community structure of mosquitoes along the China-Myanmar border. Parasit. Vectors 8, e445.

Li, P., Xing, H., Zhao, Z., Yang, Z., Cao, Y., Yan, G., Sattabongkot, J., Cui, L., Fan, Q.  2015. Genetic diversity of Plasmodium falciparum histidine-rich protein 2 in the China-Myanmar border area. Acta Trop. 152, 26-31.

Gupta, B., Reddy B.P.N., Fan, Q., Yan, G., Sirichaisinthop, J., Sattabongkot, J., Escalante, A., Cui, L. 2015. Molecular evolution of PvMSP3α block II in Plasmodium vivax from diverse geographic origins. PLoS One 10, e0135396.

Roobsoong, W., Rachaphaew, N., Chobsorn, P., Saesue, T., Roth, W., Barnes, S., Schofield, L., Cui, L., Adams, J.H., Sattabongkot, J. 2015. Analysis of culture variables for long-term in vitro culture of Plasmodium vivax. Malar. J. 14, e297.

Escalante, A.A., Ferreira, M. U., Vinetz, J.M., Volkman, S.K., Cui, L., Gamboa, D., Krogstad, D.J., Barry, A.E., Carlton, J.M., van Eijk, A.M, Pradhan, K., Mueller, I., Greenhouse, B., Pacheco, M. A., Vallejo, A.F., Herrera, S., Felger, I. 2015. Malaria molecular epidemiology: lessons from the International Centers of Excellence for Malaria Research network. Am. J. Trop. Med. Hyg. 93, S79-86.

Carlton, J.M., Volkman, S.K., Uplekar, S., Hupalo, D.N., Pereira, Alves J.M., Cui, L., Donnelly, M., Roos, D.S., Harb, O.S., Acosta, M., Read, A., Ribolla, P.E., Singh, O.P., Valecha, N., Wassmer, S.C., Ferreira, M., Escalante, A.A. 2015. Population genetics, evolutionary genomics, and genome-wide studies of malaria: A view across the International Centers of Excellence for Malaria Research. Am. J. Trop. Med. Hyg. 93, S87-98.

Moss, W. J., Dorsey, G., Mueller, I., Laufer, M.K., Krogstad, D. J., Vinetz, J.M., Guzman, M., Rosas, A., Herrera, S., Arevalo-Herrera, M., Chery, L., Kumar, A., Mohapatra, P.K., Ramanathapuram, L., Cui, L., Zhou, G., Parker, D., Nankabirwa, J.,. Kazura, J.W. 2015. Malaria epidemiology and control within the international centers of excellence for malaria research. Am. J. Trop. Med. Hyg. 93, S5-15.

Cui, L., Mharakurwa, S., Ndiaye, D., Rathod, P.K., Rosenthal, P.J. 2015. Antimalarial drug resistance: activities and findings of the ICEMR network. Am. J. Trop. Med. Hyg. 93, S57-68.

Kobayashi, T., Gamboa, D., Ndiaye, D., Cui, L., Sutton, P., Vinetz, J. 2015. Malaria diagnosis across the International Centers of Excellence in Malaria Research: platforms, performance and standardization. Am. J. Trop. Med. Hyg. 93, S99-109.

Li, Q., Yang, F., Liu, R., Luo, L., Yang, Y., Zhang, L., Liu, H., Zhang, W., Fan, Z., Yang, Z., Cui, L.,  He, Y.  2015. Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency at the China-Myanmar Border. PLoS One 10, e0134593.

Zhang, L., Yang, Y., Liu, R., Li, Q., Yang, F., Ma, L., Liu, H., Chen, X. Yang, Z., Cui, L.,  He, Y.  2015. Multiplex detection of glucose-6-phosphate dehydrogenase gene mutations using a SNaPshot assay. Int. J. Lab. Hematol. 37, 739-745.

Wang, Y., Yang, Z., Yuan, L., Zhou, G., Lee, M.-C., Fan, Q., Xiao, Y., Cao, Y., Yan, G., Cui, L.  2015. Clinical efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria at the China-Myanmar border. Am. J. Trop. Med. Hyg. 93, 577-583.

Zheng, L., Pan, Y., Feng, Y., Cui, L., Cao, Y. 2015. L-Arginine supplementation in mice enhances NO production in spleen cells and inhibits Plasmodium yoelii transmission in mosquitoes. Parasit. Vectors 8, e326.

Parker, D.M., Matthews, S.A., Sirichaisinthop, J., Kiattibutr, K., Yan, G., Zhou, G., Lee, M.-C., Fan, Q., Li, P., Sattabongkot, J., Cui, L.  2015. Microgeography and molecular epidemiology of malaria at the Thailand-Myanmar border in the malaria pre-elimination phase. Malar. J. 14, e198.

Lo, E., Zhou, G., Oo, W., Lee, M.-C., Baum, E., Felgner, P., Yang, Z., Cui, L., Yan, G. 2015. Molecular inference of sources and spreading patterns of Plasmodium falciparum malaria parasites in internally displaced persons settlements in Myanmar-China border area. Infect. Genet. Evol. 33, 189-196.

Wang, Z., Shrestha, S., Li, X., Miao, J., Yuan, L., Cabrera, M., Grube, C., Yang, Z., Cui, L.  2015. Prevalence of K13-propeller polymorphisms in Plasmodium falciparum from China-Myanmar border in 2007-2012. Malar. J. 14, e168.

Baum,E., Sattabongkot, J., Sirichaisinthop, J., Kiattibutr, K., Davies, H., Jain, A., Lo, E., Lee, M.-C., Randall, A. Z., Molina, D.M., Liang, X., Cui, L., Felgner, P. L., Yan, G. 2015. Submicroscopic and asymptomatic Plasmodium falciparum and Plasmodium vivax infections are common in western Thailand - molecular and serological evidence. Malar. J. 14, e95.

Yuan, L., Wang, Y., Parker, D., Gupta, B., Yang, Z., Liu, H., Fan,Q., Cao, Y., Lee, M., Zhou, G., Yan, G., Baird, J. K., Cui, L.  2015. Therapeutic responses of Plasmodium vivax malaria to chloroquine and primaquine treatment in northeastern Myanmar. Antimicrob. Agents Chemother. 59, 1230-1235.

Cui, L.,  Lindner, S., Miao, J. 2015. Translational regulation during stage transitions in malaria parasites. Ann. NY Acad. Sci. 1342, 1-9.

2014

Putaporntip, C., Miao, J., Sattabongkot, J., Sirichaisinthop, J., Jongwutiwes, S.,  Cui, L.  2014. The Plasmodium vivax merozoite surface protein 3β sequence reveals a clonal expansion of parasite population in southern Thailand. PLoS NTD 11, e3336.

Goel, S., Arivalagan, M., Miao, J., Cui, L., Winzeler, E., Gowda, C. 2014. Disruption of a RESA-like Plasmodium export protein gene in Plasmodium falciparum chromosome 2 confers stable chondroitin 4-sulfate adherence characteristics. J. Biol. Chem. 289, 34408-34421.

He, X., Yan, J., Zhu, X., Wang, Q., Pang, W., Qi, Z., Wang, M., Luo, E., Parker, D.M., Cantorna, M.T., Cui, L., Cao, Y. 2014. Vitamin D inhibits the occurrence of experimental cerebral malaria in mice by suppressing the host inflammatory response. J. Immunol. 193, 1314-1323. 

Gupta, B., Xu, S., Wang, Z., Sun, L., Cui, L., Yang, Z. 2014. Plasmodium falciparum multidrug resistance protein 1 (Pfmrp1) gene and its association with in vitro drug susceptibility of parasite isolates from northeast Myanmar. J. Antimicrob. Chemother. 69, 2110-2117. 

Li, P. Zhao, Z., Wang, Y., Xing, H., Parker, D.M., Yang, Z., Baum, E., Li, W., Sattabongkot, J., Sirichaisinthop, J., Li, S., Yan, G., Cui, L., Fan, Q. 2014. Nested PCR detection of malaria directly using blood filter paper samples from epidemiological surveys. Malar. J. 13, e175.

Liu, M., Miao, J., Sullivan Jr., W., Cui, L., Chen, X. 2014. Characterization of TgPuf1, a member of the Puf family RNA-binding proteins from Toxoplasma gondii. Parasit Vectors 7, e141.

Chen, K., Sun, L., Lin, Y., Hao, M., Feng, G., Wu, Y., Cui, L., Yang, Z. 2014. Competition between Plasmodium falciparum strains in clinical infections during in vitro culture adaptation. Infect. Genet. Evol. 24, 105-110.  

He, L., Nan, T., Cui, Y., Guo, S., Zhang, W., Zhang, R., Zhang, L., Tan, G., Wang, B., Cui, L. 2014. Development of a colloidal gold-based lateral flow dipstick immunoassay for rapid qualitative and semi-quantitative analysis of artesunate and dihydroartemisinin. Malar. J. 13, e127. 

Yuan, L., Hao, M., Wu, L., Zhao, Z., Rosenthal, B. M., Li, X., He, Y., Sun, L., Feng, G., Xiang, Z., Cui, L., Yang, Z. 2014. Refrigeration provides a simple means to synchronize in vitro cultures of Plasmodium falciparum. Exp. Parasitol. 140, 18-23. 

Parker, D., Wood, J., Tomita, S., DeWitte, S., Jennings, J., Cui, L. 2014. Household ecology and out-migration among ethnic Karen along the Thai-Myanmar border. Demographic Res. 30, 1129-1156. 

Wang, Z.; Liang, X., Liu, M., Siriwat, S., Tan, F., Miao, J., Cui, L. 2014. A flow cytometry-based high-throughput assay targeting all Plasmodium falciparum gametocyte stages. PLoS One 9, e93825.

Lu, F., Li, J., Wang, B., Cheng, Y., Kong, D.-H., Cui, L., Ha, K.-S., Sattabongkot, J., Tsuboi T., Han, E.-T.  2014. Profiling the humoral immune responses to Plasmodium vivax infection and identification of antigenic candidate rhoptry-associated membrane antigen (RAMA).  J. Proteomics102, 66-82.

Qin, Q., Li, Y., Zhong, D., Zhou, N., Chang, X., Li, C., Cui, L., Yan, G., Chen, X. 2014. Insecticide resistance of Anopheles sinensis and An. vagus in Hainan Island, a malaria-endemic area of China. Parasit. Vectors 7, e92.

Liu, W., Li, Y., Shaw, K.S., Learn, G.H., Plenderleith, L., Malenke, J.A., Sundararaman, S.A., Ramirez, M.A., Smith, A.G., Bibollet-Ruche, F., Ayouba, A., Locatelli, S., Esteban, A., Mouacha, F., Guichet, E., Butel, C., Ahuka-Mundeke S., Inogwabini B.-I., Ndjango, J.-B.N., Speede, S., Sanz, C.M., Morgan, D.B., Gonder, M. K., Kranzusch, P.J., Walsh, P. D., Georgiev, A.V., Muller, M. N., Piel, A K., Stewart, F. A., Wilson, M. L., Pusey, A. E., Cui, L., Wang, Z., Färnert, A., Sutherland, C. J., Nolder D.,  Hart J. A., Hart T.B., Bertolani P., Gillis A., LeBreton M., Schneider B.S., Wolfe N.D., Mpoudi-Ngole E., Delaporte E., Carter R., Culleton R. L., Shaw G. M., Rayner J. C., Peeters M., Hahn, B.H.,  Sharp, P.M. 2014. African origin of Plasmodium vivax. Nature Comm. 5, e3346.

Zhou, G.,  Sun, L., Xia, R., Yang, J., Duan, Y., Xu, J., Yang, H., Wang, Y., Lee, M.-C., Xiang, Z., Yan, G., Cui, L., Yang, Z. 2014. Clinical malaria along the China-Myanmar border area in Yunnan, China. Emerg. Infect. Dis. 20, 681-684.

Wei, X., Li, Y., Sun, X., Feng, Y., Liu, J., Jiang, Y., Shang, H., Cui, L., Cao, Y. 2014. Erythropoietin protects against murine cerebral malaria through actions on host cellular immunity. Infect. Immun. 82, 165-173.

2013

Guo, S., Cui, Y., He, L., Zhang, L., Cao, Z., Zhang, W., Zhang, R., Tan, G., Wang, B., Cui, L. 2013. Development of a specific monoclonal antibody-based ELISA to measure the artemether content of antimalarial drugs. PLoS One 8, e79154.

Wang, M., Cui, Y., Zhou, G., Yan, G., Cui, L., Wang, B. 2013. Validation of ELISA for quantitation of artemisinin-based antimalarial drugs. Am. J. Trop. Med. Hyg. 89, 1122-1128.

Li, N., Parker, D., Yang, Z., Fan, Q., Zhou, G., Ai, G., Duan, J., Lee, M.-C., Yan, G., Matthews, S.A., Cui, L., Wang, Y. 2013. Risk factors associated with slide positivity among febrile patients in a conflict zone of north-eastern Myanmar along the China-Myanmar border. Malar. J. 12, e36.

Miao, J., Wang, Z., Li, X., Cui, L. 2013. Plasmodium falciparum: Generation of pure gametocyte culture by heparin treatment. Exp. Parasitol. 135,

Miao, J., Lawrence, M., Parker, D., Jeffers, V., Ge, Y., Sullivan Jr., W. J., Cui, L. 2013. Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development. Mol. Microbiol. 89, 660-675.

Zhu, G.-H., Na, R.-H., Luo, J.-X., Meng, X.-J., Cui, L., Peng, H.-J., Chen, X., Gomez-Cambronero, J. 2013. Catalytically active Rho and Rac small-GTPases are essential for Toxoplasma gondii invasion of host cells. BMC Microbiol. 13, e125.

Taylor, J.E., Pacheco, M.A., Bacon, D., Beg, M.A., Machado, R. L. D., Fairhurst, R.M., Herrera, S.,  Kim, J.Y., Menard, D., Povoa, M.M., Villegas, L., Snounou, G., Cui, L., Zeyrek, F. Y., Escalante, A.A. 2013. The evolutionary history of Plasmodium vivax as inferred from the mitochondrial genome: the complex evolutionary history of vivax malaria in the Americas. Mol. Biol. Evol. 30, 2050-2064.

Miao M., Wang, Z., Yang, Z., Yuan, L., Parker, D.M., Putaporntip, C., Jongwutiwes, S., Xangsayarath, P., Pongvongsa, T., Moji, H., Tuong, T. D., Abe, T., Nakazawa, S., Myat Phone Kyaw, Yan, G., Sirichaisinthop, J., Sattabongkot, J., Mu, J., Su, X.-z., Kaneko, O., Cui, L. 2013. Genetic diversity and lack of artemisinin selection signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion. PLoS One 8, e59192.

Miao, J., Fan, Q., Parker, D., Li, X., Li, J., Cui, L. 2013. Puf mediates translation repression through 5'UTR in a transmission blocking vaccine candidate of the malaria parasite. PLoS Pathogens 9, e1003268.

Yan, J., Li, N., Wei, X., Li, P., Zhao, Z., Wang, L., Li, S., Li, X., Wang, Y., Yang, Z., Zheng, B., Zhou, G., Yan, G., Cui, L., Cao, Y., Fan, Q. 2013. Performance of two rapid diagnostic tests for malaria diagnosis at the China-Myanmar border area. Malar. J. 12, e73.

Zhao, J., Deng, S., Liang, J., Cao, Y., Liu, J., Du F., Cui, L., Luo, E. 2013. Immunogenicity, protective efficacy and safety of a recombinant DNA vaccine encoding truncated sporozoite asparagine-rich protein 1 against Plasmodium yoelii 17XL. Hum. Vaccines 9(5), 1-8.

Hao, M., Jia, D., Li, Q., He, Y., Yuan, L., Xu, S., Chen, K., Wu, J., Shen, L., Sun, L., Zhao, H., Yang, Z., Cui, L. 2013. In vitro responses of Plasmodium falciparum isolates from the China-Myanmar border to piperaquine and association with polymorphisms in candidate genes. Antimicrob. Agents Chemother. 57, 1723-1729.

Zhong, D., Chang, X., Zhou, G., He, Z., Fu, F., Yan, Z., Zhu, G., Xu, T., Bonizzoni, M., Wang, M.-H., Cui, L., Zheng, B., Chen, B., Yan, G. 2013. Pyrethroid resistance in the Asian malaria vector Anopheles sinensis: Varying importance of kdr and metabolic detoxification mechanisms across central and southern China. PLoS One 8, e55475.

Yuan, L., Zhao, H., Wu, L., Li, X., Parker, D., Xu, S., Zhao, Y., Feng, G., Wang, Y., Yan, G., Fan, Q., Yang, Z., Cui, L. 2013. Plasmodium falciparum populations from northeastern Myanmar display high levels of genetic diversity at multiple antigenic loci. Acta Trop. 125, 53– 59.

2012

Jangpatarapongsa, K., Xia, H., Fang, Q., Hu, K., Yuan, Y., Peng, M., Gao, Q., Sattabongkot, J., Cui, L., Li, B., Udomsangpetch, R.2012. Immunity to malaria in Plasmodium vivax infection: A study in central China. PLoS One 7, e45971.

Parker, D., Lerdprom, R., Srisatjarak, W., Yan, G., Sattabongkot, J., Wood, J., Sirichaisinthop, J., Cui, L. 2012. Monitoring of antimalarial drug resistance in Plasmodium falciparum at sentinel sites of Thailand. Malar. J. 11, e290.

Feng, Y., Zhu, X., Wang, Q., Jiang, Y., Shang, H., Cui, L., Cao, Y. 2012. Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection. Malar. J. 11, e268.

Cui, L., Wang, Z., Miao, J., Miao, M., Chandra, R., Jiang, H., Su, X, Cui, L. 2012. Mechanisms of in vitro resistance to dihydroartemisinin in Plasmodium falciparum. Mol. Microbiol. 86, 111–128.

Zhu, X., Pan, Y., Li, Y., Cui, L., Cao, Y. 2012. L-Arginine supplement enhances host immunity during early-stage Plasmodium yoelii 17XL infection. Parasite Immunol. 34, 412–420.

Talbert, P.B., Ahmad K., Almouzni, G. Ausió, J., Berger, F., Bhalla, P. L., Bonner, W. M., Cande, W. Z., Chadwick, B.P., Chan, S.W. L., Cross, G. A. M., Cui, L., Dimitrov, S. I., Doenecke, D., Eirin-López, J. M., Gorovsky, M. A., Hake , S. B., Hamkalo, B. A., Holec, S., Jacobsen, S. E., Kamieniarz, K., Khochbin, S., Ladurner, A.G., Landsman, D.,. Latham, J. A., Loppin, B., Malik, H. S., Marzluff, W. F., Pehrson, J. R., Postberg, J., Sing6, M.B.,Schneider, R.,  Mitchell Smith, M., Thompson, E., Torres-Padilla, M.-E., Tremethick, D. J., Turner, B.M., Waterborg, J H.., Wollmann, H., Yelagandula, R., Zhu, B., Henikoff, S. 2012.  A unified phylogeny-based nomenclature for histone variants. Epigenetics & Chromatin 5, e7.

Zhu, X., Pan, Y., Li, Y., Liu, Y., Shang, H., Gowda, D.C., Cui, L.*, Cao, Y.* 2012.Targeting Toll-like receptors by chloroquine protects mice from experimental cerebral malaria. Int. Immunopharmacol. 13, 392-397. (Corresponding authors)

Liu, X. Tao, Z.-Y., Fang, Q, Wang, X.-M., Zhang, H., Stoute, J. A. Xia, H., Cui, L. 2012. A case of congenital Plasmodium vivax malaria from a temperate region in Central China. Malar. J. 11, e182.

Wang, Z., Parker, D., Meng, H., Wu, L., Li, J., Zhao, Z., Zhang, R., Fan, Q., Wang, H., Cui, L.* Yang, Z.,* 2012. In vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to major ACT drugs and polymorphisms in potential target genes. PLoS ONE  7, e30927. (corresponding authors)

Chen, X., He, Y., Liu, Y., Olias, P., Rosenthal, B. M., Cui, L., Zuo, Y., Yang, Z. 2012. Infections with Sarcocystis wenzeli are prevalent in the chickens of Yunnan Province, China, but rare or absent from the flocks of domesticated pigeons and ducks. Exp. Parasitol. 131, 31-34.

Cui, L., Wang, Z., Jiang, H., Parker, D., Wang, H., Su, X, Cui, L.  2012. Lack of association of the S769N mutation in Plasmodium falciparum SERCA (PfATP6) with resistance to artemisinins. Antimicrob. Agents Chemother.  56, 2546-2552.

Zhu, X., Pan, Y., Cui, L.*, Cao, Y*. 2012. Polysaccharides from the Chinese medicinal herb Achyranthes bidentata enhance antimalarial immunity during Plasmodium yoelii 17XL infection in mice. Malar. J. 11, e49.

Che, P., Cui, L., Kutsch, O., Cui, L., Li, Q. 2012. Developing a high throughput screening assay for antimalarial drug discovery. Assay Drug Dev. Tech. 10, 61-68.

Miao, M., Yang, Z., Patch, H., Huang, Y., Escalante, A.A., Cui, L. 2012. Plasmodium vivax populations revisited: an investigation of vivax mitochondrial genomes with a focus on the parasites from the temperate zone. BMC Evol. Biol. 12, e22.

Feng, H., Zhu, X., Qi, Z., Wang, Q., Wang, G., Pan, Y., Li, Y., Zheng, L., Jiang, Y., Shang, H., Cui, L., Cao, Y. 2012. Transient attenuated foxp3 expression on CD4+ T cells treated with 7D4 mAb contributes to the control of parasite burden in DBA/2 mice infected with lethal Plasmodium chabaudi chabaudi AS. Scand. J. Immunol. 75, 46-53.

Cui, L., Yan, G., Sattabongkot, J., Cao, Y., Chen, B., Cao, Y., Fan, Q., Parker, D., Sirichaisinthop, J., Su, X., Yang, H., Yang, Z., Wang, B., Zhou, G. 2012. Challenges and prospects for malaria elimination in the Greater Mekong Subregion. Acta Trop. 121, 240-245.

Cui, L., Yan, G., Sattabongkot, J., Cao, Y., Chen, B., Chen, X., Fan, Q., Fang, Q., Jongwutiwes, S., Parker, D., Sirichaisinthop, J., Kyaw, M. P., Su, X.-z., Yang, H., Yang, Z., Wang, B., Xu, J., Zheng, B., Zhong, D., Zhou, G. 2012. Malaria in the Greater Mekong Subregion: heterogeneity and complexity. Acta Trop. 121, 227-239.

Gillrie, M.R., Lee, K., Monestier, M., Gowda, D.C., Cui, L., Hien, T. T., Day, N.P. J., Ho, M. 2012. Plasmodium falciparum histones induce human endothelial pro-inflammatory response and barrier dysfunction. Am. J. Pathol.180, 1028-1039.

2011

Wang, Q.-Y., Nangong, Z.-Y., Yang, J., Song, P., Wang, Y., Cui, L., Cui, L. 2011. Toxic activity of a protein complex purified from Xenorhabdus nematophila HB310 to Plutella xylostella larvae. Insect Sci., 1-8.

Feng, H., Zheng, L., Zhu, X., Wang, G., Pan, Y., Li, Y., Yang, Y., Lin, Y., Cui, L., Cao. Y. 2011. Genetic diversity of malaria transmission-blocking vaccine candidates in Plasmodium vivax isolates from Yunnan Province, China. Vectors & Parasites 4, e224.

Liu, Z., Miao, J. Cui, L. 2011. Gametocytogenesis in malaria parasites: commitment, development and regulation. Future Microbiol. 6, 1351-1369. (invited review)

Tian, M., Chen, Y., Wu, L., Rosenthal, B.M., Liu, X.,  He, Y.,  Dunams, D.B., Cui, L., Yang, Z. 2011. Phylogenetic analysis of Sarcocystis nesbitti (Coccidia: Sarcocystidae) suggests a snake as its probable definitive host. Vet. Parasitol. 183, 373-376.

Zhong, D., Bonizzoni, M., Zhou, G., Wang, G., Vardo-Zalik, A., Cui, L., Yan, G., Zheng, B. 2011. Genetic diversity of Plasmodium vivax malaria in China and Myanmar. Infect. Genet. Evol.11, 1419-1425.

Lu, F., Gao, Q., Cao, J., Chotivanich, K., Xia, H, Udomsangpetch, R., Cui, L., Sattabongkot, J. 2011. In vitro drug sensitivity of temperate Plasmodium vivax isolates from central China. Am. J. Trop. Med. Hyg. 85, 197-201.

Roobsoong, W., Roytrakul S., Sattabongkot, J., Li, J., Udomsangpetch, R., Cui, L. 2011. Determination of the Plasmodium vivax schizont stage proteome. J. Proteomics 74, 1701-1710.

Bonizzoni, M., Bourjea, J., Chen, B., Crain, B.J., Cui, L., Fiorentino, V., Hartmann, S., Hendricks, S., Ketmaier, V., Ma, X., Muths, D., Pavesi, L., Pfautsch, S., Rieger, M.A., Santonastaso, T., Sattabongkot, J., Taron, C.H., Taron, D.J., Tiedemann, R., Yan, G., Zheng, B., Zhong, D. 2011. Permanent Genetic Resources added to Molecular Ecology Resources Database. Mol. Ecol. Resour. 11, 935-6.

Chen, X, Zuo, Y., Rosenthal, B.M., He, Y., Cui, L., Yang, Z. 2011. Sarcocystis sinensis is an ultrastructurally distinct parasite of water buffalo that can cause foodborne illness but cannot complete its life-cycle in human beings. Vet. Parasitol. 178, 35-39.

Yang, Z., Li, C., Miao, M., Zhang, Z., Sun, X., Meng, H., Li, J., Fan Q., Cui, L. 2011. Multidrug-resistant genotypes of Plasmodium falciparum, Myanmar. Emerg. Infect. Dis. 17, 498-501.

Miao, J., Cui, L. 2011. Rapid isolation of single malaria parasite-infected red blood cells by cell sorting. Nature Protocols 6, 140-146.

Huang, Y., Yang, Z., Putaporntip, C., Miao, M., Wei, H., Zou, C., Jongwutiwes, S., Cui, L. 2011. Isolation and identification of a South China strain of Plasmodium inui from Macaca fascicularis. Vet. Parasitol. 176, 9-15.

Xiang, Z., He, Y., Zhao, H., Rosenthal, B. M., Li, X., Zuo, Y., Feng, G., Cui, L.*, Yang, Z.* 2011. Sarcocystis cruzi: Comparative studies confirm natural infections of buffaloes. Exp. Parasitol. 127, 460-466. (*Corresponding authors)

2010

Miao, M., Yang, Z., Cui, L., Ahlum, J., Huang, Y., and Cui L. 2010. Different allele prevalence in the dihydrofolate reductase and dihydropteroate synthase genes in Plasmodium vivax populations from China. Am. J. Trop. Med. Hyg. 83, 1206-1211.

Miao, J., Fan, Q., Cui, L., Li, X., Wang, H., Ning, G., Reese, J.C., Cui, L. 2010. The MYST family histone acetyltransferase regulates gene expression and cell cycle in malaria parasite Plasmodium falciparum. Mol. Microbiol. 78, 883–902.

Meng, H., Zhang, R., Yang, H., Miao, J., Fan, Q., Su, X.-z., Cui, L.*, Yang, Z.* 2010. In vitro sensitivity of Plasmodium falciparum clinical isolates from the China-Myanmar border area to quinine and association with polymorphism in the Na+/H+ exchanger.  Antimicrob. Agents Chemother.  54, 4306–4313 (*Corresponding authors)

Miao, J., Li, X. and Cui, L. 2010. Cloning of Plasmodium falciparum by cell sorting.  Exp. Parasitol. 126, 198-202.

Cui, L. and Miao J. 2010. Chromatin-mediated gene regulation in malaria parasites. Eukaryot. Cell 9, 1138-1149. (Invited review)

Putaporntip, C., Udomsangpetch, R., Ferreira, M., Kanbara, H., Cui, L. Jongwutiwes, S. 2010. Genetic diversity and population structure of the Plasmodium vivax merozoite surface protein-5 locus. Gene 456, 24-35.

Mu, J., Myers, R. A., Jiang, H., Liu, S., Ricklefs, S., Waisberg, M., Chotivanich, K., Wilairata, P., Krudsood, S., White, N.J., Udomsangpetch,  R., Cui, L., Ho, M., Ou, F., Li, H., Song, J., Li, G., Wang, X., Seila, S., Sokunthea, S., Socheat, D., Sturdevant, D.E., Porcella, S.F., Fairhurst,  R.M., Wellems, T.E., Awadalla, P., Su, X. 2010. Genome-wide positive selection, recombination hotspots, and loci associated with Plasmodium falciparum resistance to antimalarial drugs. Nature Genet. 42, 268-271.

Miao, J., Li, J., Fan, Q., Li, X.-L., Li, X.-Y., Cui, L. 2010. The Puf family RNA-binding protein PfPuf2 regulates sexual development and sex differentiation in the malaria parasite Plasmodium falciparum. J. Cell Sci. 123, 1039-1049.

Chuangchaiya, S., Jangpatarapongsa, K., Chootong, P., Sirichaisinthop, J., Sattabongkot, J., Pattanapanyasat, K., Chotivanich, K., Troye-Blomberg, M., Cui, L., Udomsangpetch, R. 2010. Plasmodium vivax controls Plasmodium falciparum survival by modulating host immune response. Clin. Exp. Immunol. 160, 233-239.

2009

Westenberger,  S.J., Cui, L., Dharia, N. Winzeler, E., Cui, L. 2009. Genome-wide nucleosome mapping of Plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes. BMC Genomics 10, e610.

Cui, L., Trongnipatt, N., Sattabongkot, J., and R. Udomsangpetch. 2009. Culture of Exoerythrocytic Stages of the Malaria Parasites Plasmodium falciparum and P. vivax. In “Parasite-host Interactions – Methods in Molecular Biology” (Rupp, S. and Sohn, K., eds.), Vol. 470, pp 263-273.

Putaporntip, C., Jongwutiwes, S., Grynberg, P., Cui, L., Hughes, A.L. 2009. Nucleotide sequence polymorphism at the apical membrane antigen-1 locus reveals population history of Plasmodium vivax in Thailand. Infect. Genet. Evol. 9, 1295-1300.

Cui, L., Su, X-z. 2009. The discovery, mechanisms of action, and combination therapy of artemisinin. Exp. Rev. Anti Infect. Ther.  7, 999-1013. (Invited review)

Putaporntip, C., Jongwutiwes, S., Ferreira, M., Kanbara, H., Udomsangpetch, R., Cui, L. 2009. Limited global diversity of the Plasmodium vivax merozoite surface protein 4 gene. Infect. Genet. Evol. 9, 821-826.

Fan, Q., Miao, J., Cui, L., Cui, L. 2009. Characterization of protein arginine methyltransferase I from Plasmodium falciparum. Biochem. J. 421,107-118.

Putaporntip, C., Hongsrimuang, T., Seethamchai, S., Kobasa, T. Limpitikul, K., Cui, L., Jongwutiwes, S. 2009. Differential prevalence of Plasmodium infections and cryptic Plasmodium knowlesi malaria in humans, Thailand. J. Infect. Dis. 199, 1143-1150.

2008

Jangpatarapongsa, K., Chootong, P., Sattabongkot, J., Sirichaisinthop, J., Tungpradabkul, S., Hisaeda, H., Troye-Blomberg, M., Cui, L., Udomsangpetch, R. 2008. Plasmodium vivax parasites alter the balance of myeloid and plasmacytoid dendritic cells and induction of regulatory T cells. Eur.  J. Immunol. 38, 1-9.

Zhong, D., Afrane, Y., Githeko A., Cui, L., Menge, D.M., Yan, G. 2008. Molecular epidemiology of drug-resistant malaria in western Kenya highlands. BMC Infect Dis. 8(1), e105.

Chookajorn, T., Ponsuwanna, P., Cui, L. 2008. Mutually exclusive var gene expression in the malaria parasite: multiple layers of regulation. Trends Parasitol. 24, 455-461.

Yang, H., Yang, Y., Yang, P., Li, X., Gao, B., Zhang, Z., Yang, Z., Cui, L. 2008. Monitoring Plasmodium falciparum chloroquine resistance in Yunnan Province, China, 1981-2006. Acta Trop. 108, 44-49.

Cui, L., Miao, J., Wang, J., Li, Q., and Cui, L. 2008. Plasmodium falciparum: Development of a transgenic line for screening antimalarials using firefly luciferase as the reporter. Exp. Parasitol. 120, 80-87.

Cui, L., Miao, J., Furuya, T., Li, X., Su, X.-z., and Cui, L. 2008. The histone acetyltransferase inhibitor anacardic acid leads to changes in global gene expression during in vitro Plasmodium falciparum development. Eukaryot. Cell 7, 1200-1210.

Seethamchai, S., Putaporntip, C., Malaivijitnond, S., Cui L., Jongwutiwes, S. 2008. Malaria and hepatocystis spp. in wild macaques, southern Thailand. Am. J. Trop. Med. Hyg. 78, 646-653.

Cui, L., Fan, Q., Cui, L., Miao, J. 2008. Histone lysine methyltransferases and demethylases in Plasmodium falciparum.  Int. J. Parasitol. 38, 1083-1097.

Chen, H., Minakawa, N., Cui, L., Yan, G. 2008. Conspecific sharing of breeding sites by anopheline female mosquitoes (Diptera: Culicidae) inferred from microsatellite markers.  J. Insect Behav. 21, 24-33.

2007

Grimberg,  B.T., Udomsangpetch R., Xainli,  J., McHenry, A., Panichakul, T., Sattabongkot, J., Cui, L., Bockarie, M., Chitnis, C., Adams, J., Zimmerman, P. A., King, C.L. 2007. Plasmodium vivax invasion of human erythrocytes inhibited by antibodies directed against the Duffy binding protein. PLoS Med. 4, e337, 1940-1948.

Cox-Foster, D.L., Conlan, S., Holmes, E.C., Palacios, G., Evans, J.D., Moran, N.A., Quan, P.L., Briese, T., Hornig, M., Geiser, D.M., Martinson, V., Vanengelsdorp, D., Kalkstein, A.L., Drysdale, A., Hui, J., Zhai, J., Cui, L., Hutchison, S.K., Simons, J.F., Egholm, M., Pettis, J.S., Lipkin, W.I. 2007. A metagenomic survey of microbes in honey bee colony collapse disorder. Science 318, 283-287.

Al-Wabel M.A., W. K. Tonui, L. Cui, S.K. Martin, R.G. Titus. 2007. Nucleoside hydrolase, a soluble exo-antigen of Leishmania, protects susceptible BALB/c mice from challenge with L. major. Am. J. Trop. Med. Hyg. 77, 1060-1065.

Zhong, D., Afrane, Y., Githeko, A., Yang, Z., Cui, L., and Yan, G. 2007. Plasmodium falciparum genetic diversity in highlands and lowlands of western Kenya. Am. J. Trop. Med. Hyg. 77, 1060–1065.

Sun, X., Cui, L., Li, Z. 2007. Diversity and phylogeny of Wolbachia infecting Bactrocera dorsalis (Diptera: Tephritidae) populations from China. Envion. Entomol. 36, 1283-1289.

Panichakul, T., Sattabongkot, J., Chotivanich, K., Sirichaisinthop, J., Cui, L., and Udomsangpetche, R. 2007. Production of erythropoietic cells in vitro for continuous culture of Plasmodium vivax. Int. J. Parasitol. 37, 1551-1557.

Fan, Q., Li, S., Wang, L., Zhang, B., Ye, B., Zhao, Z., and Cui, L. 2007. The genome sequence of the multinucleocapsid nucleopolyhedrovirus of the Chinese oak silkworm Antheraea pernyi. Virology 366, 304-315.

Yang, Z., Zhang, Z., Sun, X., Wan, W., Cui, L., Zhang, X., Zhong, D., Yan, G., Cui, L. 2007. Molecular analysis of chloroquine resistance in Plasmodium falciparum in Yunnan Province, China. Trop. Med. Pub. Health 12, 1051-1060.

Cui, L., Miao, J., Furuya, T., Li, X., Su, X.-z., and Cui, L. 2007. PfGCN5 mediated histone H3 acetylation plays a key role in gene expression in Plasmodium falciparum. Eukaryot. Cell 6, 1219-1227.

Cui, L., Chen, X., Li, L., and Li, J. 2007. Identification of Trichoplusia ni ascovirus 2c virion structural proteins. J. Gen. Virol. 88, 2194-2197.

Udomsangpetch, R., Somsri, S., Panichakul, T., Chotivanich, K., Sirichaisinthop, J., Yang, Z., Cui, L., and J. Sattabongkot. 2007. Short-term in vitro culture of field isolates of Plasmodium vivax using umbilical cord blood. Parasitol. Int. 56, 65-69.

Cui L., J. Miao, and L. Cui. 2007. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: Inhibition of histone acetylation and generation of reactive oxygen species. Antimicrob. Agents Chemother. 51, 488-494.

2006

Yang Z., Miao, J., HuangY., Li X., Putaporntip C., Jongwutiwes S., Gao Q., Udomsangpetch R., Sattabongkot J., and L. Cui. 2006. Genetic structures of geographically distinct Plasmodium vivax populations assessed by PCR/RFLP analysis of the merozoite surface protein 3β gene. Acta Trop. 100, 205-212.

Vichchathorn P., R. Jenwithisuk, S. Leelaudomlipi, S. Tungpradabkul, S. Hongeng, L. Cui, J. Sattabongkot, R. Udomsangpetch. 2006. Induction of specific immune responses against the Plasmodium vivax liver-stage via in vitro activation by dendritic cells. Parasitol. Int. 55, 187-193.

Miao, J., X. Li,  Z. Liu, C. Xue, H. Bujard, L. Cui. 2006. Immune responses in mice induced by prime-boost schemes of the Plasmodium falciparum apical membrane antigen 1 (PfAMA1)-based DNA, protein and recombinant modified vaccinia Ankara vaccines. Vaccine 24, 6187-6198.

Sattabongkot, J., Yimamnuaychoke, N., Leelaudomlipi, S., Rasmeesothat, M., Jenwithisuk, R., Coleman, R.E., Udomsangpetch, R., L. Cui, Brewer, T.G. 2006.  Establishment of a human hepatocyte line that supports in vitro development of the exoerythrocytic stages of the malaria parasites Plasmodium falciparum and P. vivax. Am. J. Trop. Med. Hyg. 74, 708-715.

Jangpatarapongsa, K., J. Sirichaisinthop, J. Sattabongkot, L. Cui, S.M. Montgomery, S. Looareesuwan, M. Troye-Blomberg, and R. Udomsangpetch. 2006. Memory T cells protect against Plasmodium vivax infection. Microbes Infect. 8, 680-686.

Waitayakul, A., S. Somsri, J. Prachumsri, S.  Looareesuwan, L. Cui, R. Udomsangpetch. 2006. Natural human response to salivary gland proteins of Anopheles mosquito. Acta Trop. 98, 66-73.

Miao J., Q. Fan, L. Cui, J. Li, J. Li and L. Cui. 2006. The malaria parasite Plasmodium falciparum histones: organization, expression, and acetylation. Gene 369, 53-65.

2005

Li, J., L. Cui, D.L. Rock and J. Li. 2005. Novel glycosidic linkage in Aedes aegypti chorion peroxidase: N-mannosyl tryptophan. J. Biol. Chem. 280, 38513–38521.

Shen, M., X. Yang, D. Cox-Foster and. L. Cui.  2005. The role of varroa mites in infections of Kashmir bee virus (KBV) and deformed wing virus (DWV) in honey bees.  Virology 342, 141-149.

Cui, L., Q. Fan, Y. Hu, S.A. Karamycheva, J. Quackenbush, B. Khuntirat, J. Sattabongkot, J. M. Carlton. 2005. Gene discovery in Plasmodium vivax through sequencing of ESTs from mixed blood stages. Mol. Biochem. Parasitol.144, 1-9.

Shen, M., L. Cui, N. Ostiguy and D. Cox-Foster.  2005. Intricate transmission routes and interactions between picorna-like viruses (Kashmir bee virus and sacbrood virus) with the honey bee host and the parasitic varroa mite. J. Gen. Virol. 86, 2281-2289.

Mascorro, C., K. Zhao, B. Khuntirat, J. Sattabongkot, G. Yan, A. Escalante and L. Cui. 2005. Molecular evolution and intragenic recombination of the merozoite surface protein MSP-3α from the malaria parasite Plasmodium vivax in Thailand. Parasitology 131, 25-35.

Cui, L., K. Zhao and Y. Chen. 2005. The Molecular Biology of Insect Polydnaviruses. In “Recent Research Advances in Entomology” (T.-X. Liu, ed., Texas A&M), Higher Education Publisher. Pp. 46-77.

Chen, Y., J. Hu and Cui, L. 2005. Insect Baculoviruses in Pest Control: Research and Applications. In “Recent Research Advances in Entomology” (T.-X. Liu, ed., Texas A&M), Higher Education Publisher. Pp. 79-87.

Barr, N. B., L. Cui, and B. A. McPheron. 2005. Molecular systematics and sequence analysis of a nuclear gene, period, in the genus Anastrepha (Tephritidae).  Ann. Entomol. Soc. Am.  98, 173-180.

Zhou, G., J. Sirichaisinthop, J. Sattabongkot, J. Jones, O. N. Bjørnstad, G. Yan, and L. Cui. 2005. Spatio-temporal distribution of falciparum and vivax malaria incidences in Thailand. Am. J. Trop. Med. Hyg. 72, 256-262.

2004

Liu, F., L. Cui, D. Cox-Foster and G. Felton. 2004. Characterization of a salivary gland lysozyme in larval Helicoverpa zea. J. Chem. Ecol. 30, 2439-2457.

Fan, Q., J. Li, M. Kariuki and L. Cui.  2004. Characterization of PfPuf2, member of the Puf family RNA-binding proteins from the malaria parasite Plasmodium falciparum. DNA Cell Biol. 23, 753-760.

Fan, Q., L. An and L. Cui.  2004. PfADA2, a Plasmodium falciparum homologue of the transcriptional coactivator ADA2 and its in vivo association with the histone acetyltransferase PfGCN5. Gene 336, 251-261.

Sattabongkot, J., T. Tsuboi, G. E. Zollner, J. Sirichaisinthop and L. Cui.  2004.  Plasmodium vivax Transmission: Chances for Control? Trends Parasitol.  20, 192-198.

Fan, Q., L. An and L. Cui.  2004.  Plasmodium falciparum histone acetyltransferase: A yeast GCN5 homologue involved in chromatin remodeling. Eukaryot. Cell 3, 264-276.

2003

Cui, L., C. N. Mascorro, K. A. Rzomp, Q. Fan, B. Khuntirat, G. Zhou, H. Chen, G. Yan and J. Sattabongkot.  2003.  Genetic diversity and multiple infections of Plasmodium vivax malaria in western Thailand.  Am. J. Trop. Med. Hyg. 68, 613-619.

Zhao, K. and L. Cui.  2003.  Molecular characterization of the major virion protein gene from the Trichoplusia ni ascovirus.  Virus Genes 27, 93-102.

Cui, L., A. A. Escalante, M. Imwong and G. Snounou.  2003.  The genetic diversity of Plasmodium vivax populations.  Trends Parasitol.  19, 220-226.

2002

Cui, L., Q. Fan, and J. Li.  2002. The malaria parasite Plasmodium falciparum encodes members of Puf RNA binding protein family with conserved RNA binding activity. Nucleic Acids Res. 30, 4607-4617.

2001

Rajasekariah, G. R., J. R. Ryan, S. R. Hillier, L. Yi, J. W. Stiteler, L. Cui, A. M. Smithyman and S. K. Martin.  2001.  Optimisation of an ELISA for the serodiagnosis of visceral leishmaniasis using in vitro derived promastigote antigens. J. Immunol. Methods 252, 105-119.

Cui, L., G. R. Rajasekariah and S. K. Martin.  2001.  A nonspecific nucleoside hydrolase from Leishmania donovani: Implications for purine salvage by the parasite. Gene 280, 153-162.

Cui, L., K. A. Rzomp, Q. Fan, S. K. Martin, and J. Williams.  2001.  Plasmodium falciparum: Differential display analysis of gene expression during gametocytogenesis.  Exp. Parasitol. 99, 244-254.

2000

Cui, L., S. Luckhart and R. Rosenberg.  2000.  Molecular characterization of a prophenoloxidase cDNA from the malaria mosquito Anopheles stephensi.  Insect Mol. Biol. 9, 127-137.

Cui, L., A. I. Soldevila and B. A. Webb.  2000.  Relationships between polydnavirus gene expression and host range of the parasitoid wasp Campoletis sonorensis.  J. Insect Physiol. 46, 1397-1407.

1999

Cui, L., S.-H. Chang, D. Strickman and E. Rowton.  1999.  Frequency of Wolbachia infection in laboratory and field sand fly (Diptera: Psychodidae) populations.  J. Amer. Mosquito Control Assoc. 15, 571-572.

1998

Shelby, K. S., L. Cui and B. A. Webb.  1998.  Polydnavirus-mediated inhibition of lysozyme gene expression and the antibacterial response.  Insect Mol. Biol. 7, 265-272.

Luckhart, S., Y. Vodovotz, L. Cui and R. Rosenberg. 1998.  The mosquito Anopheles stephensi limits malaria parasite development with inducible synthesis of nitric oxide.  Proc. Natl. Acad. Sci. USA 95, 5700-5707.

Webb, B. A. and L. Cui.  1998.  Relationships between polydnavirus genomes and viral gene function.  J. Insect Physiol. 44, 785-793.

1997

Cui, L. and B. A. Webb.  1997.  Promoter analysis of a cysteine-rich Campoletis sonorensis polydnavirus gene. J. Gen. Virol. 78, 1807-1817.

Cui, L. and B. A. Webb.  1997.  Homologous sequences in the Campoletis sonorensis polydnavirus genome are implicated in replication and nesting of the W segment family. J. Virol. 71, 8504-8513.

Cui, L., A. Soldevila and B. A. Webb.  1997.  Expression and hemocyte-targeting of a Campoletis sonorensis polydnavirus cysteine-rich gene in Heliothis virescens larvae.  Arch. Insect Physiol. Biochem. 36, 251-271.

1996

Cui, L. and B. A. Webb.  1996.  Isolation and characterization of a member of the cysteine-rich gene family from Campoletis sonorensis polydnavirus.  J. Gen. Virol. 77, 797-809.

1994

Wang, Y., R. Gaugler and L. Cui.  1994.  Variability of insect immune response to entomopathogenic nematodes.  J. Nematol. 26, 11-18.

1993

Cui, L., R. Gaugler and Y. Wang.  1993.  Penetration of steinernematid nematodes (Nematoda: Steinernematidae) into Japanese beetle larvae, Popillia japonica (Coleoptera: Scarabaeidae).  J. Invertebr. Pathol. 62, 73-78

Research Interests

Disease Biology and Ecology

Molecular parasitology; medical entomology; host-parasite interactions

Malaria Research